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KMID : 0613820090190081104
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Journal of Life Science
2009 Volume.19 No. 8 p.1104 ~ p.1111
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The Effects of Medicinal Herb-made Sikhe on Damage and Lipid Levels of Liver in Rats Fed High-cholesterol Diets
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Park Hyun-Suk
Yang Kyung-Chun
Yang Kyung-Mi
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Abstract
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This study was conducted to evaluate the effect of Sikhe made by medicinal herb on the functional level of liver. Water extract Ⅰ(12.9% W/W) and Ⅱ(25.8% W/W) were obtained from medicinal materials: Caragana Sinica, Glycyrrhiza uralensis, Atractylodes rhizoma alba, Atractylodes rhizoma alba, Crataegus pinnatifida, Paeonia lactiflora Pasll., Hordeum vulgare Linne, Oryza sativa Linne, ginger, peer and jujube. Experimental groups were divided into the control diet group (C), high fat diet group (HF), high fat diet treated with 5% extract I group (HFEⅠ) and high fat diet treated with 5% extract Ⅱ group (HFE Ⅱ). In sensory evaluation, overall quality scores associated with color, aroma, flavor and taste were significantly higher in water extract Ⅱ than in water extract Ⅰ. After investigating functional and lipid levels of livers in rats, we found that the administration of water extract Ⅰ or water extract Ⅱ to the high fat diet group (HF) did not affect the gain of body weight but mildly reduced GOT or GPT activity in the high diet group. Moreover, administration of these medicinal herbal extracts significantly decreased the levels of total lipid, triglyceride and total cholesterol in the high fat diet group (HF). However, administration of these medicinal herbal extracts did not affect the level of phospholipid. In conclusion, as Sikhe made by medicinal herb slightly decreased the activity of GOT or GPT and amount of lipid in liver, prevention against high fat diet is thought to be important for liver protection.
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KEYWORD
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Medicinal herb, Sikhe, liver function, antihyperlipidemia
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